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Factors affecting individual response include baseline tissue health, severity of issues being addressed, consistency of use, lifestyle factors, current medications, and genetic variables

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Autophagy receptors (P62, NBR1, NDP52, OPTN, TAX1BP1) specifically recognize ubiquitin chains via their LC3-interacting regions, binding to microtubule-associated protein 1A/1B-light chain 3 (LC3) on autophagosomal membranes and directing the engulfment of damaged mitochondria