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Several other preclinical observations fit well with a contribution of d-serine in AD-related neurotoxicity: neuronal cell death induced by NMDA is strongly reduced in cerebral tissues depleted in d-serine after a pre-treatment with dAAO (Katsuki et al., 2004) as well as in organotypic hippocampal slices pre-treated with the recombinant d-serine deaminase, an enzyme 100 fold more active than dAAO in degrading the amino acid (Shleper et al., 2005)

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Loss of the blue color, cloudiness, or unusual viscosity changes are the primary visual indicators of degradation