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My symptoms are severe enough that I’m concerned about getting the second dose (despite the medical community saying that I should)

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We know that the final mixed concentration to be: 1000ppm × (100%-50%) +166ppm × 50% = 583ppm With a COC of 6, 6 times makeup volume is required at 50% of 20 m 3 , this will therefore be: MakeupVolumeBeforeBlowdown = (6 - 1) x 10m 3 = 50m 3 With a sanity check: (583ppm x 20m 3 + 166ppm x 50m 3 ) / (20m 3 ) = 998ppm Which is close enough