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The ROS-mediated plant defense response is further more complex and is dependent on factors like the life style of pathogen (biotrophy/necrotrophy), the type of plant–pathogen interaction (compatible/incompatible interactions) and the stage of plant development (Govrin and Levine, 3)

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In more detail, an abnormal cholinergic system regulates and promotes changes in the metabolism of amyloid precursor protein and tau phosphorylation, triggering neurotoxicity, neuroinflammation, and neuronal death

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