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One study in healthy adults with normal coagulation (blood clotting) status found that daily supplementation with 1,000 IU (670 mg) of RRR -α-tocopherol for 12 weeks decreased γ-carboxylation of prothrombin, a vitamin K-dependent factor in the coagulation cascade (127)
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The potential mechanism responsible for the increasing blood levels of 25(OH)VD could be that the improvement in the GSH status reduces oxidative stress and upregulates vitamin D-metabolizing genes, thereby increasing blood levels of 25(OH)VD (Figure 2)
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