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2 Macrophage/microglia origin, classical activation, and functions The current view is that during embryonic development, precursor cells from the yolk sac or embryo infiltrate organs and differentiate into tissue-resident macrophages ( Macrophages and microglia are remarkably plastic, heterogeneous cells with multiple immunological functions

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Methods: 23 swine underwent craniotomy and were randomized into 5 groups, defined by 1-, 2-, or 4-hrs occlusion followed by 4-hrs recanalization