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Mechanism Validation : Confirming VEGF/eNOS pathways requires molecular analysis

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Four combinations are currently approved for first-line treatment in m ccRCC (3 TKI-ICI-axitinib plus pembrolizumab, cabozantinib plus nivolumab and lenvatinib plus pembrolizumab—and 1 ICI-ICI-nivolumab plus ipilimumab) [13]