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Molecular structures of sulforaphane and its metabolites: Sulforaphane... | Download Scientific Diagram

This structural feature provides a crucial clue for explaining their pharmacological mechanisms: they can exert potent anti-inflammatory effects in a hormone-like manner—for instance, by inhibiting NLRP3 inflammasome assembly and activating SIRT1—yet are often not accompanied by the severe side effects commonly associated with glucocorticoids, such as broad immunosuppression or osteoporosis (Hu et al., 2024

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[DOI] [PubMed] [Google Scholar] 38.Bohm B., Heinzelmann S., Motz M., Bauer G