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the inventors also surprisingly found inhibitory activity with certain embodiments of the invention where R 1 is methyl with dual positional substitutions (see e.g., compounds 2j, 2m, 2k, and 2l, Table 2)
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Cagrilintide is chemically complex — same fatty-acid conjugation chemistry as semaglutide — so synthesis shortcuts produce ineffective product, not just lower-potency product
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