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Primary Receptor Biology: The Mechanistic Starting Point MT-2 (cyclo[Nle4, Asp5, D-Phe7, Lys10]-α-MSH) acts primarily through melanocortin receptors: MC1R (Ki~0.3nM, dominant melanocyte/keratinocyte effect), MC3R (~0.9nM) and MC4R (~1.1nM, CNS/metabolic effects)