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GLP-1 activation suppresses appetite and slows gastric emptying, while GIP signaling is thought to enhance energy expenditure, improve insulin sensitivity in adipose tissue, and reduce gastrointestinal side effects through central mechanisms

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a 2004 drug development review in Current Opinion in Investigational Drugs that described AOD-9604 moving into Phase IIa human trials, without reporting a single result from that trial Dominikowski et al