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Interestingly, the effects of MVA biosynthetic pathway inhibitors (i.e., statins, bisphosphonates) on TAMs suggest that TIM can be regulated by MVA biosynthetic pathway (158–160)
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This direct (i.e., non-Michael) mechanism is in contradiction with the solution chemistry experiments 4–6,8 and QM calculations of the thiol additions of various activated olefins
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