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Vitamin B12: Targeted nutritional support Long-term B12 supplementation can provide: Sustained support for nervous system health Ongoing prevention of megaloblastic anemia Potential cognitive benefits, particularly in older adults Support for bone health and reduced risk of osteoporosis For individuals with chronic B12 deficiency or absorption issues, long-term supplementation may be necessary to maintain optimal health

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Conversely, EBI2 could exert its functions by guiding B cells to particular microenvironments that either facilitate B cell maturation and differentiation or support the survival of PC [33]