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Treatment with thioacetamide and 2/3 partial hepatectomy in rats, which induced both GCLC and GS expression, increased the GSH synthesis capacity by 161–200% (Huang et al., 1998, Lu et al., 1999c)

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Occurrence of the disease usually presents after age 50, affecting 100–300 out of every 100,000 people, manifesting motor symptoms in the majority of patients [123]