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Serious B12 deficiencies can impair heart and neurological functions, leading to a wide range of serious symptoms including tinnitus, severe joint pain, memory problems, depression, anxiety, poor muscle function, ataxia and changes in reflexes

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At the doses used in Schneider-Helmert's intranasal protocols, the total absolute peptide mass per administration was in the low-to-mid microgram range for an average adult, a quantity far smaller than the milligram-level dosing commonly cited in peptide forums