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Standard cycling involves 4-8 weeks of use followed by 2-4 weeks off before resuming if needed
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35 The evolutionarily conserved, ~90-residue-long PDZ sequence allows the scaffolding proteins to perform two major functions: 1) anchoring the intracellular C-terminus of transmembrane proteins (TJs, ion channels, receptors, etc.) and 2) establishing scaffolding networks via interactions with other PDZ proteins through PDZ–PDZ dimerization
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