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The precise mechanism through which HMGB1 induces EMT in asthma remains unclear, but it may potentially involve RAGE and the phosphatidylinositol 3′ -kinase/Akt/glycogen synthase kinase 3β/β-catenin (PI3K/Akt/GSK3β/β-catenin) signaling pathway (92) or the RAGE/NF-κB signaling pathway (93)