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What causes pruritus after Vitamin B12 (Cobalamin) injection?

How is B!2 Inject Kit supplied Cyanocobalamin Injection, USP 1000 mcg/mL NDC 0517-0031-25 1 mL Fill in a 2 mL Vial Boxes of 25 NDC 0517-0032-25 10 mL Multiple Dose Vial Boxes of 25 NDC 0517-0130-05 30 mL Multiple Dose Vial Boxes of 5 Store at 20°-25°C (68°-77°F)

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Effect sizes calculated in perprotocol primary efficacy analysis (which referred to outcome measures calculated after excluding weeks with deviations from target L-dopa oral dose) are reported in black