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[Note: this paragraph includes indirect mechanistic evidence from non-PD models
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The phosphorylation-mimetic peptide S249/T252, derived from the retinoblastoma protein (RB), represents a novel advancement designed to emulate the phosphorylated state of RB at specific residues, S249 and T252, which are key targets of CDK4/6 kinases (Jin et al., 2019)
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