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This may lead to changes in synaptic excitability, such as presynaptic inhibition of neurotransmission (Sladeczek et al., 1993) or induction of postsynaptic responses (Platt, 2007)

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The Arg143 residue near loop IV and the bound Cu 2+ at the active site played an important role in catalysis by offering the microenvironment for superoxide recruitment to the active site 30,52