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Key differences between the two enzyme families are that the -type enzymes are smaller (~35 kDa) and highly specific for reduction of oxidized Trx, whereas metazoan TrxRs are larger proteins (~55 kDa) that evolved from Gsr and are capable of reducing a broad range of substrates (Arner, 2009

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This is due to factors like population growth, aging populations, and unhealthy lifestyles ( Various factors can increase the risk of developing HTN