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In metformin users, the increase in MMA levels was also associated with significant worsening of symptoms of neuropathy, assessed by a validated neuropathy score[49]

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However, it has been estimated that on average there are sufficient glycogen reserves to sustain brain energetic demands for around 10 min, assuming an average resting cerebral metabolic rate of glucose (CMRglc) of 1 μmol/g/min (Barros et al