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Add one new peptide per week, document your response, and only add the next when the current one is well tolerated

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Mutations in several of these splicing factors, including PRP-19/PRPF19 66 , UAF-1/U2AF2 66,101 , PRP-8/PRPF8 102 , RSP-7/SRSF11 103 , and RBM-5/RBM10 104 , have been linked to VRJS-like neurodevelopmental defects in humans, suggesting convergent pathomechanisms