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In the thione state, mesomeric release of the lone pair of electrons on the nitrogen atom of the amino group generates a thiolate anion explaining the weak thiol-like character of ESH with a thiol p K a of 10.8 (Table 1 [60])

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No obstante, la síntesis natural del glutatión en las células del cerebro se apoya en el reciclaje de sus componentes, y, por consiguiente, el aumento del glutatión en la circulación sanguínea puede aún así favorecer esta operación