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In the 26-week phase 2 trial, nausea affected 20% to 47% of participants across the 0.3–4.5 mg dose range, against 18% on placebo — the range widens with dose, which is why the trial escalated participants over up to six weeks before holding a target dose (Lau et al., 2021)

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They are often used to treat deficiencies that can lead to conditions such as anemia, neuropathy, and other neurological disorders