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Treatment with sodium dichloroacetate (DCA), proposed to increase mitochondrial ATP production by inhibiting pyruvate dehydrogenase kinase (PDK) and thereby activating pyruvate dehydrogenase, was observed to improve fatigue scale scores of ME/CFS patients (19)

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The decrease in circulating melatonin levels over the course of a person’s lifetime, which coincides with a more general decline in many circadian rhythms as people get older, is a compelling indicator that melatonin, even at physiological levels, may have an important role to play in this process