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In obese adipose tissue, excessive ROS production from NADPH oxidases and impaired ETCs induces mitochondrial DNA (mtDNA) damage, which escapes into the cytoplasm and circulation as damage‐associated molecular patterns (DAMPs), activating TLR9 and NLRP3 inflammasome pathways to trigger pro‐inflammatory cytokine cascades such as IL‐1β and IL‐18 [118, 119]
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