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Intranasal Administration for Pain: Oxytocin and Other Polypeptides

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Molecular formula: C₁₉₁H₂₉₄N₅₂O₅₈S₂ Molecular weight: ~ 4226.8 g/mol Peptide length: 37 amino acids Disulfide bonds: 1 (between Cys² and Cys⁷) Modification: Lipidation at Lys²⁸ via γ-glutamic acid linker and C16 fatty diacid Type: Long-acting amylin analogue (peptide drug) Half-life: ~8 days (due to lipidation and albumin binding) Source: PubChem In scientific terms, Cagrilintide’s function begins with its activation of amylin receptors , including the calcitonin receptor complexes found in brain regions tied to appetite monitoring