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Therefore, the descendants of the PGCs with 100% mutant mtDNA must have been eliminated prior to the formation of the mature oocytes
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In the combined therapy, IMiDs increase the direct toxic effects of CD38 mAbs, including lysosomal-mediated apoptotic pathways, and increase CD38 expression on Treg cells, resulting in enhanced elimination of Treg cells [96, 97]
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