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TLR2 was found to favor the expression of C3 and CFB, the pivotal factors of the alternative pathway, in both RPE cells and mononuclear phagocytes

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The glutaminase inhibitor, telaglenastat (CB-839), has been tested in combination with carfilzomib and dexamethasone in relapsed and/or refractory MM, and newer inhibitors like DRP-104 (sirpiglenastat) are in solid tumor clinical trials (184–186)