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mitochondrial, SHMT2) catalyzes the transfer of the beta carbon of serine to tetrahydrofolate (THF) to form glycine and one-carbon units, 5,10-methylene-THF (Figure 1), which is critical for nucleotide synthesis

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Then you need to have intrinsic factors on the gut lining to bring B12 into circulation, transcobalamin proteins to move it around the body and finally, pancreatic enzymes for absorption