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The levels of uric acid in the body are primarily due to a person’s rate of turnover of cells as well as the rate of excretion and reabsorption in the kidneys.[ref] In addition to someone’s natural rate of uric acid production and excretion, the following can influence uric acid levels: Diet – high intake of fructose and purines (meat, seafood) increases uric acid[ref] Genetics – uric acid levels are considered about 70% heritable (due to genetics)[ref] Kidney disease doubles the risk of gout[ref] Fasting and rapid weight loss increase uric acid (temporarily) Type-2 diabetes[ref] Medications Blood cancers Medications: The thiazide class of diuretics used for high blood pressure significantly increases the risk of high uric acid in men.[ref] Overproduction vs