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Synthetic Agonists DMXAA: Despite natural STING agonists being able to directly trigger the STING signaling pathway, they are usually characterized by unstable, synthetic chemicals and thus must be developed to achieve higher treatment efficiency

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These results establish PRIMPOL repriming as part of the MUS81-dependent replication restart mechanism that operates at sites of R-loop-mediated transcription-replication conflicts to maintain genomic stability