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Stimulation of ion transport by ascorbic acid through inhibition of 3′;5′-cyclic-AMP phosphodiesterase in the corneal epithelium and other tissues

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Moreover, trivalent species have been found to inhibit the activity of 3-phosphoinositide-dependent kinase-I (PDK-1) and mammalian target of rapamycin (rictor-mTOR), and to cause decreased phosphorylation of Akt, resulting in decreased GLUT4 recruitment to the plasma membrane of insulin-stimulated adipocytes