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It has been reported that ATP13A2 has a hydrophobic N-terminal domain that specifically recognizes lipid signals that can enhance its protective role against mitochondrial stress ( ATP13A2 gene) found in Caenorhabditis elegans cause defects in autophagy and lysosomal function and exhibit characteristic PD phenotypes, including dysregulation of iron metabolism ( ATP13A2 mutation impairs mitochondrial function in C
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