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“Controversy over the role of DHODH in ferroptosis regulation” Although ferroptosis was initially thought to be primarily executed at the plasma membrane, a pivotal study by Boyi Guan’s group highlighted mitochondria as a potential site of critical lipid peroxidation, particularly under conditions of GPX4 inactivation or in GPX4-low cell lines 23
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The ineffectiveness of AEDs and their possible side effects might contribute to some risks to the patients including neuronal damage
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