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Since metformin improves insulin sensitivity and steatosis in MASLD 58 , these findings support a protective role of GADD45β in limiting inflammation, fibrosis, and progression to MASH
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Retatrutide and newer agents Retatrutide , a triple agonist targeting GLP-1, GIP, and glucagon receptors, is still in clinical development but early data suggest similar gastrointestinal side effect profiles
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