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At the first and second follow-up visits, CBL-514 1.2 mg/cm 2 reduced fat by 5.38% and 4.16%, respectively, versus 16.53% and 13.88% with CBL-514 at 1.6 mg/cm 2 , respectively, and 23.13% and 21.85% with CBL-514 at 2.0 mg/cm 2 , respectively (Figure 3)

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If a disk starts to bulge or crack, the fluid can put pressure on nerves, causing pain