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For 20 years, it seemed "obvious" that NSAIDs blunt training adaptation. Trappe 2002 showed ibuprofen suppressed muscle protein synthesis 24 hours after exercise. Mikkelsen 2009 showed a local NSAID infusion blocked satellite

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Tetracycline and amoxicillin combined with BPC-157 caused premature vomiting and expulsion in animal models, though the relevance to human use remains unclear