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A Couple Things That May Cause You Concern Occasionally I receive calls from parents concerned about a bluish or reddish discoloration under the skin and they are worried that this is a bad thing, that they have hurt their child, or that the dark spot will be permanent

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Cagrilintide, the second generation (2020s) Novo Nordisk took the Pramlintide concept and applied the same half-life extension strategy that they used with Semaglutide: Kept the proline substitutions (anti-amyloid) Added a C20 fatty diacid via a γ-Glu linker to a lysine residue, albumin binding Additionally stabilized the N- and C-terminal positions Result: Cagrilintide with a half-life of 6.6 days (vs 50 minutes for Pramlintide)