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36 H 1 -Receptor Agonists & H 3 -Receptor Antagonists Beyond serotonergic signaling, central histamine signaling has been implicated in appetite regulation, and the weight gain associated with antipsychotic medication may reflect the inhibition of H 1 -histamine receptor signaling

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Inborn errors of metabolism (e.g., vitamin B6-dependent convulsions or B6-responsive anemia)