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Weight loss was accompanied by improvements in cardiometabolic parameters, including a decrease in systolic blood pressure (-9.9 mmHg) and waist circumference (-17.5 cm) (placebo-adjusted: 6.7 mmHg and 13.5 cm, respectively)

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We note many other attractive cysteine bioconjugation methods have also been developed, while their fast versions remained to be explored, including umpolung strategy [58] , π-clamp mediated conjugation [59] , reactive peptide interface conjugation, [60] and phosphorus (V) electrophiles [61]

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