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21 To estimate the changes in prescribing over time and the effect of the COVID-19 pandemic, we compared prepandemic data from the years 2015 to 2019 to the years from 2020 to 2024

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Theoretical concerns: angiogenic activity warrants caution in patients with active malignancy (no tumour-promoting effects observed in any preclinical study, but oncology populations have not been formally studied)