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Neuronal GSH production is believed to be primarily mediated by astrocytic GSH release, and astrocytic GSH production is rate-limited by cysteine and the enzyme glutamateβcysteine ligase.4,5 In addition to providing cysteine for GSH production, NAC has been shown to scavenge oxidants directly, particularly the reduction of the hydroxyl radical, Β·OH and hypochlorous acid.6 Oral administration of GSH alone does not adequately restore GSH levels
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While tRNA Ser is a canonical elongator tRNA that adopts a 7/5 fold (where 7 and 5 indicate a number of base pairs in the acceptor and TΨC arms, respectively), tRNA Sec is an unusual tRNA that adopts either a 9/4 fold in eukaryotes (49,50) or an 8/5 fold in prokaryotes (51)
