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Fatty acid signaling also plays a very important role in adipogenesis as various fatty acid species such as PUFAs, MUFAs, and MCFAs were shown to regulate preadipocyte differentiation at various degrees depending on their composition
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High-throughput screening campaigns against the GLP-1 receptor and other class B GPCRs consistently yielded low hit rates for small molecules, and the few hits that emerged typically showed micromolar potency, insufficient for therapeutic applications
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