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C-reactive protein a promising biomarker of COVID-19 severity

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In macrophages, 4-octyl itaconate, a cell-permeable derivative of endogenous itaconate, inhibits Nrf2 degradation pathway and promotes transcription of target genes, including SLC7A11, glutathione-cysteine ligase, and Gpx4, alleviating sepsis-induced acute lung injury [118]