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In a systematic review and meta-analysis, depression was associated with significantly increased oxidative stress as measured by biomarkers of oxidative DNA damage (8-OHdG) and lipid peroxidation (F₂-isoprostanes) compared to non-depressed controls (35–37)

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The unusual structure of the lipid A family derived from the lipopolysaccharide of Halomonas magadiensis is reported herein