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426 A double-blind placebo-controlled trial gave 132 healthy adults between ages 35 and 65 years either 430 mg, 860 mg, or 1,290 mg of a wild green oat extract (Cognitaven) or placebo once daily for 29 days

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Early agents such as hexamethonium were the first effective antihypertensives, demonstrating that pharmacologic reduction of blood pressure could prevent cardiac complications (left panel)