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Chronic sleep deprivation suppresses the same axis LR3 IGF-1 is supplementing, and cortisol elevation from chronic stress drives the protein-degradation pathways LR3 IGF-1 is suppressing

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25 Volkov et al., who found that benefits were regardless of B12 status, discuss the possibility that patients in their study were deficient despite serum levels being within normal limits, as no other biomarker tests were carried out