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Unfortunately, there is no evidence that any of these agents modify the underlying pathophysiology of peripheral neuropathy.(16) Studies have shown that high doses of methylcobalamin improved nerve conduction in streptozotocin-diabetic rats.(17) This was again demonstrated in experimental acrylamide neuropathy, where high doses of methylcobalamin were associated with a significant increase in the rate of motor nerve fibre regeneration.(18) This may be the mechanism through which methylcobalamin acts to modify and treat the underlying pathophysiology of peripheral neuropathy

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In the original plan, the proposal was to achieve this per country, then to combine all data together